Season Two was the second season of 1000-lb. Sisters. It premiered on January 4, 2021, with "Life-Altering News", and concluded on March 8, 2021, with "Do or Die". In total, ten episodes were aired.
Tammy struggles to get back on the weight-loss wagon in order get approved for surgery, but this time, her brother, Chris, joins her on the journey. Amy must deal with one very big life-altering repercussion of having had her surgery.
|Date Aired||Episode Name|
|7||1||January 4, 2021||Life-Altering News|
|8||2||January 11, 2021||Tippin' the Scales|
|9||3||January 18, 2021||Wake-Up Call|
|10||4||January 25, 2021||A Fork in the Road|
|11||5||February 1, 2021||Dropping Bombs|
|12||6||February 8, 2021||There's Something About Jerry|
|13||7||February 15, 2021||Jerry Bites Back|
|14||8||February 22, 2021||Everybody Hurts|
|15||9||March 1, 2021||Labor of Love|
|16||10||March 8, 2021||Do or Die|